We only have a couple weeks left of NFL regular-season game picks. Yet the end-of-year schedule allows no mercy when it comes to the tricky nature of these predictions.

Only two Week 16 games opened with double digit point spreads. The Ravens are 10-point favorites over the Browns, and the Seahawks are 10-point favorites over the Cardinals. The rest of the schedule features a blend of toss-up games and matchups that exist not to impact the playoff picture, but to ruin our chances at a perfect week of picks.

For example, the Texans, Steelers, Redskins, Dolphins and Cowboys were favored by a field goal or less against the Buccaneers, Jets, Giants, Bengals and Eagles, respectively. Of course, we’re used to the toss-ups by now. Bring them on for a couple more weeks.

Here are our Week 16 NFL picks straight up, all the way through the Monday night game in Minnesota. All odds are courtesy of SportsInsider.com.

MORE: Get the latest NFL odds & betting advice from Sports Insider

NFL picks, predictions for Week 16

  • Houston Texans (-2) at Tampa Bay Buccaneers

Saturday, 1 p.m. ET, NFL Network

With a red-hot Jameis Winston, the Buccaneers have scored 35 or more points three times during their four-game winning streak. Which good considering their defense allows 28.4 points per game. The latter stat is good news for the Texans as they try to maintain their AFC South lead and playoff positioning. Also working against Tampa Bay is the fact that injuries are piling up around Winston, meaning he might be more inclined to force more throws. Even against Houston’s shaky pass defense, bad things happen for the Bucs when Winston tries to force too many throws.

Pick: Texans 27, Buccaneers 21

  • Buffalo Bills at New England Patriots (-6)

Saturday, 4:30 p.m. ET, NFL Network

This isn’t exactly the defense Tom Brady and the Patriots’ struggling offense wants to see as they fight for playoff positioning in the AFC. Likewise, Buffalo’s offense is in for a struggle against the NFL’s top scoring defense as it attempts to steal the division title from New England. In what’s expected to be a close, low-scoring game, special teams and penalties will be factors. The Patriots have the edge in both areas.

Pick: Patriots 20, Bills 14

  • Los Angeles Rams at San Francisco 49ers (-6 1/2)

Saturday, 8:15 p.m. ET, NFL Network

Few expected this to be a game between teams that lost last week, but the Falcons upset the 49ers and the Cowboys beat up on the Rams to set both San Francisco and LA back in the playoff picture. Now the Rams are a long shot to make the playoffs, and the 49ers are stuck in a wild-card spot with their second-place division standing. San Francisco’s injuries are a concern, but Kyle Shanahan’s offensive creativity will be greater than that of Sean McVay, and the 49ers will eliminate the defending NFC West champs.

Pick: 49ers 26, Rams 23

  • New Orleans Saints (TBD) at Tennessee Titans

Sunday, 1 p.m. ET, Fox

This pick will be added upon completion of the Saints’ Monday night game against the Colts.

Pick: TBD

  • Baltimore Ravens (-10) at Cleveland Browns

Sunday, 1 p.m. ET, CBS

Cleveland’s blowout win in Baltimore earlier this season is arguably the most confusing game result of the year given what we now know about both teams. The Ravens, of course, are on track for the No. 1 seed in the AFC playoffs, and the Browns are on the brink of elimination. There’s no reason to believe Cleveland’s defense can do enough to slow down Lamar Jackson in the rematch now that Baltimore has found its groove on offense. And on the other side of the ball, the struggles with and around Baker Mayfield will continue.

Pick: Ravens 31, Browns 20

  • Pittsburgh Steelers (-3) at New York Jets

Sunday, 1 p.m. ET, CBS

The Steelers are not yet in must-win mode when it comes to their standing in the AFC playoff picture, but they’re close. If Pittsburgh wins out, it will make the postseason as the No. 6 seed. There also are scenarios in which the Steelers would make the playoffs after splitting their last two games, but considering they play the Ravens in Week 17, they can’t afford to lose to the Jets. Despite New York being 5-9 and out of the playoff picture, it can give Pittsburgh trouble with its stingy rush defense, putting pressure on whoever plays QB for the Steelers. As usual, though, Pittsburgh has just enough of an edge in coaching to make the difference.

Pick: Steelers 20, Jets 13

  • New York Giants at Washington Redskins (-2)

Sunday, 1 p.m. ET, Fox

This is one of two games Sunday that will impact the top of the 2020 NFL Draft order, with Bengals at Dolphins being the other. Thanks to strength of schedule, Washington entering Week 16 is stuck in the No. 4 selection spot behind Miami and New York, all at 3-13. So the loser of the Giants-Redskins game will be in great shape for the No. 2 overall pick (and, potentially, Chase Young), especially if the Dolphins beat the Bengals. As for the actual football game, it’s a toss-up, so we’ll take the team that has Saquon Barkley over the team with the NFL’s 28th-ranked rush defense.

Pick: Giants 27, Redskins 21

  • Carolina Panthers at Indianapolis Colts (-6 1/2)

Sunday, 1 p.m. ET, Fox

This pick will be added upon completion of the Colts’ Monday night game against the Saints.

Pick: TBD

  • Jacksonville Jaguars at Atlanta Falcons (-7)

Sunday, 1 p.m. ET, Fox

This game means nothing for the NFL playoff picture, something for the 2020 NFL Draft order and everything for the two head coaches. Most assume the Doug Marrone era in Jacksonville will end after Week 17 if not earlier, but Dan Quinn’s future in Atlanta isn’t as clear. The Falcons started a new winning streak with their upset win over the 49ers last week, and back at home against the Jags, they have matchup advantages across the board. They’ll make it three straight wins in the players’ apparent effort to save Quinn’s job.

Pick: Falcons 28, Jaguars 25

  • Cincinnati Bengals at Miami Dolphins (-1)

Sunday, 1 p.m. ET, CBS

Here’s the other NFL Draft order game of the week. The Bengals simply need to lose either of their last two games to seal the No. 1 overall selection in 2020. Even though a loss would be beneficial for the Dolphins, as well, their effort in the second half of the season has made clear they could not care less about the draft order. Cincinnati dropping this game would make sense for a lot of reasons, but why would the NFL make sense?

Pick: Bengals 30, Dolphins 27

  • Detroit Lions at Denver Broncos (-6 1/2)

Sunday, 4:05 p.m. ET, CBS

Outside of the Detroit and Denver TV markets, would anybody notice if the Lions and Broncos just didn’t play this game? Draft positioning is the only thing on the line. We’ll take the home team.

Pick: Broncos 23, Lions 20

  • Oakland Raiders at Los Angeles Chargers (-5 1/2)

Sunday, 4:05 p.m. ET, CBS

Outside of the Oakland of Los Angeles TV markets, would anybody notice if the Raiders and Chargers just didn’t play this game? Draft positioning is the only thing on the line. We’ll take the home team.

Pick: Chargers 23, Raiders 20

  • Dallas Cowboys (-2 1/2) at Philadelphia Eagles

Sunday, 4:25 p.m. ET, Fox

Alright, Eagles: Here is your chance to begin to right all the wrongs of your 2019 season. While the scenario for the Cowboys is simple — beat Philadelphia, eliminate the rival from the playoffs and win the NFC East title — the Eagles have a more complicated path to the playoffs. But, first things first, they have to beat Dallas at home. Considering the injuries still impacting the Eagles, we don’t like their chances against a Cowboys team finally feeling good about itself.

Pick: Cowboys 28, Eagles 24

  • Arizona Cardinals at Seattle Seahawks (-10)

Sunday, 4:25 p.m. ET, Fox

The Seahawks shouldn’t lose to the Cardinals. Then again, the 49ers weren’t supposed to lose to the Falcons last week, either. For that reason, Seattle can’t afford to let this become a trap game ahead of its Week 17 rematch (and likely NFC West title game) against San Francisco. Thanks to great matchups across the board against the Cardinals’ struggling defense, the Seahawks should be just fine and will stick as the No. 1 seed for at least one more week.

Pick: Seahawks 28, Cardinals 20

  • Kansas City Chiefs (-5) at Chicago Bears

Sunday, 8:20 p.m. ET, NBC

This game stuck as the “Sunday Night Football” feature for Week 16 despite the Bears being eliminated from the playoffs, and we can thank the Patrick Mahomes ratings factor. Now coupled with a legit defense, Kansas City’s offense is rolling again just in time for a playoff push. To be in a better seeding position for that run, the Chiefs will be motivated to take care of the Bears. Chicago’s still-solid defense doesn’t have enough answers for Mahomes and Co. 

Pick: Chiefs 27, Bears 17

  • Green Bay Packers at Minnesota Vikings (-4)

Monday, 8:15 p.m. ET, ESPN

The Vikings are capable of beating the Packers at home without Dalvin Cook, but if the running back plays through his shoulder injury against Green Bay’s shaky run defense, Minnesota will be in good shape. The Packers will find some spots for chunk yardage as they always do with Aaron Rodgers, but the Vikings, motivated to challenge for the NFC North title and make a deep playoff run, are clicking at the right time.

Pick: Vikings 26, Packers 24

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