While much of the story and comedy was centred around Sheldon’s slapdash coupling with Leonard Hofstadter (Johnny Galecki), he did eventually find a girlfriend.
When Amy (Mayim Bialik) came on to the scene fans weren’t sure if the difficult scientist would be able to commit fully.
However, as viewers now know, the pair did end up getting married, but they may have realised this earlier in season seven episode 21, The Anything Can Happen Recurrence.
Unhappy about this progression, Sheldon tells the psychic: “No insult intended, but you’re a fraud.
“Your profession is a swindle and your livelihood is dependent on the gullibility of stupid people. Again. No offence.”
However the psychic later goes on to tell Sheldon’s future, which fans may be able to read quite a lot from.
She explains: “Your spirit guides are telling me there’s a woman in your life you’re having problems with. A specific woman you’re in a romantic relationship with.
“Does she work in a similar field to you? They’re telling me you’re having difficulty being close to her. He should give himself to this relationship.”
She concluded: “Once he does, all his other pursuits will come into focus.”
As fans will know, this is exactly what went on to happen. Sheldon gave himself fully to the relationship he had with Amy, and the pair went on to work together in harmony, and win the Nobel Prize.
Since then, it has seemed Amy star Mayim has been missing her colleagues, as revealed by her recent Instagram post.
She posted an image of herself back stage during filming The Big Bang Theory alongside colleagues Kaley and Bernadette star Melissa Rauch.
Mayim captioned the image: “I miss them @melissarauch@kaleycuoco.”
Fans of the show began praising the star, and telling her how much they want to see more of the show now that it is over.
One wrote: “Will miss you this season but thank heavens for reruns!”
A second said: “We do too! Can believe no more BBT!!! CBS needs to do a spin off!!!!”
While a third exclaimed: “We miss you all… wish you could come back!”
The Big Bang Theory season 12 is available on CBS and All4.